About SATB2 Associated Syndrome

What is SATB2 Associated Syndrome?

You may have seen the name “SATB2 Associated Syndrome” before, other names for this condition are “Glass Syndrome” and “2q33.1 deletion/microdeletion/mutation”.

But what does “SATB2” mean?

SATB2 is the name of the gene responsible for the rare genetic condition which is SATB2 Associated Syndrome. SATB2 is also an acronym which clinicians use to outline the main symptoms associated with this condition.

S

Speech and Language delays – Speech may be limited or absent

A

Craniofacial Abnormalities – bones of the skull (cranio) and face (facial) such as; cleft, high palate, swallowing or and feeding difficulties

T

Teeth anomalies

B

Behavioural symptoms with or without bone or brain irregularities

2

Visible by age 2 yrs – The group of symptoms that typically surface in a child with SATB2 are more obvious after the age of two

A Brief History of SATB2 Associated Syndrome

The first reported case of SATB2 Associated Syndrome was for a 16 year old boy in 1989 diagnosed by Dr Ian Glass. At the time Dr Glass named the condition after himself calling it “Glass Syndrome”. Dr Glass identified a deletion of some genetic information in chromosome 2 (2q32.2-q33.1 microdeletion) which he determined was the cause of the condition.

Since then our understanding of SAS has grown, we now know that SAS can occur from more than one genetic change and we understand more about the condition itself. In 2003 the SATB2 gene was identified (FitzPatrick et al.) and in 2014 researchers proposed a new clinically recognisable name for the syndrome (Döcker et al.). Ideally, names of genetic conditions should be medically informative and meaningful to the condition. This is why these days we refer to the condition as SATB2 Associated Syndrome instead of “Glass Syndrome”.

The SATB2 Gene:

We can think of our genes as recipes for the body to make proteins, these proteins can be used to send messages in the body.

SATB2 gene gives the recipe to make the SATB2 protein. This SATB2 protein is incredibly important. The SATB2 gene sends messages for controlling the turning off and turning on of a network of other genes involved in development of the brain, bones, teeth, and palate. Without the SATB2 protein the body doesn’t know which of these recipes it needs to make causing a range of downstream effects.

When genetic changes in the SATB2 gene occur it can present as SATB2 Associated Syndrome. These changes can include mutations (misspellings), deletions (missing information), or duplication (extra information) in the SATB2 gene.

This is also why we see such a variable range of symptoms in people with SATB2 Associated Syndrome.

What could SATB2 Associated Syndrome mean for your loved one?

Summary for Health Professionals

SATB2 Associated Syndrome, is a genetic condition caused by a change (mutation) to the SATB2 Gene.
Whilst it is classified as rare, there are over 700 reported cases worldwide.

SATB2 Associated Syndrome is an autosomal dominant condition, however, SATB2 genetic changes are normally not inherited from either parent. This means this genetic change has occurred for the first time (De Novo) in the individual with SATB2 Associated Syndrome.

Due to the change not being inherited from a parent, it means there is a low risk (1-2%) of this genetic change occurring again in biological children.

Common clinical features of SATB2 Associated Syndrome include:

Speech anomalies – Individuals with SATB2 Associated Syndrome may have absent or limited speech.

Developmental delay and Intellectual disability – All documented cases of individuals diagnosed with SATB2 Associated Syndrome have reported developmental delay and intellectual disability. The extent of the delay can vary from person to person, however approximately half of individuals with SATB2 Associated Syndrome have severe developmental delay.

Dental anomalies – Individuals with SATB2 Associated Syndrome may experience a range of dental anomalies including abnormal shape of upper incisors, dental crowding, hypodontia (missing one or more teeth), delayed dentition (eruption of teeth occurs later than expected, may have no teeth erupted by age of 18 months), supernumerary teeth (having extra teeth), and delayed root formation. It is also common for individuals with SATB2 Associated Syndrome to regularly grind their teeth.

Palate anomalies – Approximately half of individuals with SATB2 Associated Syndrome have some form of palate anomaly. This can include cleft palate (an opening in the roof of the mouth), high palate (when the roof of the mouth rises higher than usual), bifid uvula (uvula that’s forked or split) and submucous cleft palate (an opening in the tissue covering the soft palate in the mouth).

Brain anomalies – Individuals with SATB2 Associated Syndrome may have clinical presentations of brain anomalies including: Dilated ventricles, small corpus callosum, abnormal myelination, and increased T2 white matter signals around ventricles.

Feeding issues – Majority of individuals with SATB2 Associated Syndrome experience feeding issues including oropharyngeal dysphagia (choking/gagging, overstuffing/eating). and excessive drooling.

Behaviour Issues – Younger children with SATB2 Associated Syndrome may have frequent tantrums and difficulties dealing with changes. Older individuals can be at higher risk of developing aggression towards themselves and others. Clinicians may consider Applied Behaviour Analysis and family therapy.
Sleep Issues – Individuals with SATB2 Associated syndrome can have difficulties with both falling asleep and staying asleep throughout the night. Clinicians may consider an overnight EEG sleep study if caregivers notice sleeping difficulties. Other treatments ranging from low dose melatonin to Alpha Agobnist medications may be considered by clinicians.

Less common features include skeletal anomalies (osteopenia, pectus deformities, kyphosis/lordosis, talipes, and scoliosis), growth restriction, vision issues (strabismus, refractive errors, squints), congenital heart defects, genitourinary anomalies, neurological anomalies (seizures, ataxia spasticity), and sparse thin hair.

Clinicians should be aware of the various health obstacles individuals with SATB2 Associated Syndrome encounter in order to best provide or refer on for assistance. Care teams should aim to provide integrated care to address each patients’ needs.

It is also important to note that individuals with SATB2 Associated Syndrome can have a higher than average pain threshold. Clinicians should consider this whilst providing care, as an SATB2 Associated Syndrome individual may not react in pain to indicate an injury.

References:

Glass IA, Swindlehurst CA, Aitken DA, McCrea W, Boyd E. Interstitial deletion of the long arm of chromosome 2 with normal levels of isocitrate dehydrogenase. J Med Genet. 1989;26:127–130.

Bengani, H., Handley, M., Alvi, M., Ibitoye, R., Lees, M., Lynch, S. A., Lam, W., Fannemel, M., Nordgren, A., Malmgren, H., Kvarnung, M., Mehta, S., and 22 others. Clinical and molecular consequences of disease-associated de novo mutations in SATB2. Genet Med. 19: 900-908, 2017.

Döcker D, Schubach M, Menzel M, Munz M, Spaich C, Biskup S, Bartholdi D. Further delineation of the SATB2 phenotype. Eur J Hum Genet. 2014;22:1034–9.

FitzPatrick DR, Carr IM, McLaren L, Leek JP, Wightman P, Williamson K, Gautier P, McGill N, Hayward C, Firth H, Markham AF, Fantes JA, Bonthron DT. Identification of SATB2 as the cleft palate gene on 2q32-q33. Hum Mol Genet. 2003;12:2491–501.

A special thanks to Genetic Councillor, Rachel Muir, for working with SATB2 Connect.

CONTACT

PO Box 2012

HORNSBY

Westfield, NSW 1635

hello@satb2.org.au

Acknowledgement of Country – SATB2 Connect Ltd is a national organisation made up of families across Australia. We acknowledge the Traditional Owners of Country throughout Australia and recognise their continuing connection to land, water and culture. We pay our respects to their elders past and present and emerging.

ABN: 84654538986

ACN: 654538986

new person

their info

neurologist

Individuals with SATB2 need MRI and EEG scans because seizures are a common symptom of SATB2. Families and parents may require further explanation related to behaviours reminiscent in ADHD, ASD and OCD.

Kim Bowen

Kim’s daughter Scarlett was diagnosed with SATB2 Associated Syndrome in April 2020 at the age of 5. Like many others, the path towards Scarlett’s diagnosis was protracted and isolating. Once the diagnosis was received, a world of support and friendship opened up within the international SATB2 family which their family is grateful for. She hopes to be able to draw on this experience to help other families facing similar circumstances.

Kim began a degree in Occupational Therapy straight out of high school and although she ultimately chose a different career path, she brings to the Foundation an ongoing interest in Allied Health and a keenly developed sense of respect and empathy for fellow families with loved ones who have been diagnosed with SATB2 Associated Syndrome.

Prior to becoming a mum, Kim worked within the Buying and Planning departments of some of Australia’s most well known retailers including Rebel Sport, David Jones, Mothercare, and Babies Galore. Within these roles, she was able to utilise her organisational and analytical skills in the negotiation of contracts, procurement, and development of products, sales analysis, and stock allocation. She also used her project management skills to facilitate and coordinate the stocking of new stores. Kim hopes to put these skills to good use within the Foundation.

Kim developed a passion for being involved in charities at a young age. At the age of 16 she became part of the inaugural Junior Branch Management Committee at her local PCYC. She later moved into the Branch Management Committee and was involved in the governance of the club’s operations, development and implementation of local community projects, planning, and execution of fundraising events, and supervision of the club.

Kim lives in Bathurst with her husband Ross and their children, Scarlett and Jasper. She now divides her time between working in the hospitality business that Ross is the licensee of, caring for her family, and fussing over her large collection of succulents.

David Loftus-Hills

David is a father of three, and his daughter Hannah was diagnosed with SATB2 Associated Syndrome in October 2018 at the age of 3. Since first connecting with the overseas SATB2 organisations and online groups, he has watched the size of the international SATB2 community grow and is passionate about adding to the global support and research network through the development of SATB2 Gene Foundation Australia.

David has an honours degree in Mechanical and Manufacturing Engineering from The University of Melbourne and has worked in the resources industry in Western Australia for the past 20 years. This has given him a wide range of experience in project management, data analysis, building business cases, risk assessments, implementing change and leading teams.

Prior to having children, David lived in regional Western Australia and enjoyed volunteering as an Ambulance Officer and Firefighter in the local community. Now Perth-based with his wife Rachael, he loves watching his children learn and develop, and especially appreciates the efforts of Hannah’s therapists and educators as they help her go from strength to strength.

Matt Dixon

Matt is an IT Leader with over 20 years experience in management positions, gained in multinational organisations in both Sydney and London. He has worked in the telco, media, advertising and consumer goods industries, and is currently working for BeamSuntory as APAC Regional IT Director.

A father of two, Matt’s youngest son Dylan was diagnosed with SATB2 Associated Syndrome at the age of 8 years old, in 2015. Dylan’s journey has been a difficult one – he had a cleft palate repaired at Great Ormond St Hospital in London at the age of 6 months; a squint in his eye repaired at the age of one year; and for many years had a diagnosis of Global Developmental Delay. Since moving to Australia in 2014, Dylan has attended a number of schools, and finding the appropriate therapies has proven an ongoing challenge.

Matt is passionate about setting up structures to support families with SATB2 individuals and to provide more targeted therapies and respite.

Matt lives in Sydney with his wife Asa, and their two children William and Dylan. When not caring for Dylan or working, Matt’s passions are music and reading.

Dr Sarah Wilkes-Gillan

Sarah is a registered occupational therapist with a clinical background in paediatric practice. She is currently works at the University of Sydney as a lecturer in the Bachelor of Applied Science (Occupational Therapy) program at the Sydney School of Health Sciences in the Faculty of Medicine and Health. She also provides occupational therapy services to children and their families.

Sarah received her PhD from the University of Sydney in 2015 and her research focuses on developing and evaluating psychosocial interventions to improve the social participation of children with developmental disorders. Sarah has a strong interest in research and promoting evidence-based practice so children receive the most up-to-date and effective healthcare. She supervises a number of honors and Ph.D. research students and collaborates with researchers nationally and internationally on a number of research projects. Sarah has experience in a range of research methodologies and leading research projects.

Sarah is a mother of three young children and is most passionate about partnering with parents as they support their children to grow and develop – and in advancing our knowledge of how best to help children and their families.

Dr Natalie Munro

Natalie is a certified practising speech language pathologist and associate professor at The University of Sydney. Natalie is a senior fellow of the Higher Education Academy and co-editor of the International Journal of Speech-Language Pathology.

Natalie’s research and clinical interests span across child and adolescent language development and disorders. Dr Munro’s research interests include: 1) investigating individual differences in children’s speech, language and social skills development among learners who have developmental language disorder, ADHD and language-based learning disabilities, 2) intervention research and evidence-based practice to support children and adolescents with additional needs, their families, their educators and their communities.

Natalie completed her PhD in 2008 and a Graduate Certificate in Higher Education Studies in 2009. Natalie was awarded a University of Sydney Brown Equity Fellowship in 2013 and was the national tour speaker for Speech Pathology Australia in 2018. Natalie’s research collaborators include scholars from Australia, the United States, the UK and Hong Kong. Natalie is a mother of three daughters and is passionate about communication and participation for all kids!

Dr Ryan Chen

Ryan is a lecturer in occupational therapy at Sydney School of Health Sciences in the Faculty of Medicine and Health the University of Sydney, with a clinical and research background in paediatric practice. He previously worked as a paediatric occupational therapist providing services to children and their families before moving to Sydney in 2010.

Ryan completed his PhD from the University of Sydney in 2015 on the investigation of everyday social experience in individuals with autism spectrum disorders. He has a strong research interest in understanding and supporting needs of children and adults with and without disabilities in real-life participation through exploring their quality of everyday life and psychosocial well-being. Ryan has experience in quantitative research and survey design, in particular collecting and analysing multilevel and longitudinal data. His current and future research will provide evidence about what services and supports are needed to address the needs of children and their families in their daily life.

Dr Dave Parson

Dave Parsons is a current Lecturer in the School of Allied Heath at Curtin University. Dave graduated from Curtin University with a Bachelor of Occupational Therapy in 2006. Dave completed his PhD in 2020 and conducts research in the area of hand and upper limb therapy, child health, telehealth, and tertiary education.

Dave is also the Allied Health Research Lead at St John of God Public and Private Hospital, Midland. The role has the responsibility of building research skills, capacity and culture within the Allied Health professions (occupational therapy, physiotherapy, speech pathology, social work, psychology, dietetics and podiatry). Responsibilities include consulting and supporting allied health providers on their research projects, assisting with student supervision, providing advice and input into the hospital research strategy, and building relationships between professions (including medical and nursing staff) to drive high impact research.

Dr Lauren Parson

Lauren is a speech language pathologist with a background working with children and their families. She is currently working as a Research Fellow at Curtin University at the Curtin School of Allied Health in the Faculty of Health Sciences.

Lauren’s received her PhD from Curtin University in 2019, and since then her research has focused on the participation of vulnerable children and young people through the development and evaluation of psychosocial interventions, mapping lived experiences with later outcomes, and finding new ways for families to access allied health services. As a researcher, Lauren is keen to promote evidence-based practice so that effective and appropriate supports are provided to children that meet the unique needs of each child and their families. Using a range of research methodologies Lauren collaborates with colleagues across the disciplines of speech pathology, occupational therapy, social work, and psychology. Her collaborators include researchers within Australia, the United Kingdom, and Norway.

As a mother and an allied health professional, Lauren is passionate about bringing together service users and service providers to develop solutions that support the participation of all children.

Dr Abbie Najjarine

Dr Abbie Najjarine has been in private practice since 1990 giving him extensive experience in Lower Limb Biomechanics and the application of orthotic therapy. Known internationally as Dr Abbie, he has treated in excess of 150,000 patients in his clinics located in Australia and is a renowned international lecturer in Biomechanics and orthotic therapy. He is constantly invited to lecture and teach his unique ‘Najjarine Biomechanical Assessment System’(NBA System Previously known as the ‘Najjarine Assessment System’ (NAS) technique that he developed to train Podiatrists, Sports Medicine Doctors, Orthopaedic Surgeons, Rehabilitation Doctors, Chiropractors, Osteopaths and Physiotherapists, from all around the world. Dr Najjarine has trained over 50,000 practitioners world-wide.

In 1996 Abbie established the International College of Biomechanics as an educational institution that provide practitioners with increased knowledge in clinical biomechanics. The college is now known as the International Institute of Clinical Biomechanics. He is the author of the “Orthotic Revolution” and is in the process of finalising and launching is book on Advanced Clinical lower limb biomechanics which will be a full comprehensive guide designed to simplifies and add his own unique approaches and methods into an easy to follow set of principles and formulas, to create both a unique system for diagnosing biomechanical problems, and to introduce a dramatic advance in the therapeutic effectiveness of Orthotic devices and treatment modalities. Dr Najjarine is also the advisor to the China Research Rehabilitation Centre (CRRC).Its a charity organisation also that provides treatment to children with disabilities funded by the China government. Dr Najjarine was voted in 2019 to be the president of the International Association of Clinical Biomechanics in China, Taiwan, Hong Kong and Australasia. Dr Najjarine Has treated many children conditions from “growing pain’ Syndromes, Cerebral Palsy cases, SATB2, muscular dystrophy, delayed walkers, severely pigeon-toed cases, scoliosis cases and many more. Dr Najjarine is passionate about his work with children and wants to provide good foundation and provide stability control and balance.

Dr Yuri Zarate

Dr. Zarate is a Clinical Geneticist and an Associate Professor at the University of Arkansas for Medical Sciences and Arkansas Children’s Hospital. In 2014, Dr. Zarate started a research project that led to a report with the first cohort of patients with SATB2-associated syndrome (SAS). From there, he established a strong-long lasting relationship with the support group for this rare condition, created the initial dedicated SAS website (www.satb2gene.com), and launched the only available clinical registry for this syndrome. Through his leadership, Arkansas Children’s Hospital started a multidisciplinary international SAS clinic in 2017 that has now evaluated dozens of individuals from several countries. Dr. Zarate has published extensively on different aspects regarding this syndrome and activity leads and collaborates on several ongoing SAS-related research projects.

Dr Emma Palmer

Dr Emma Palmer Clinician scientist at Sydney Children’s Hospital Network & University of New South Wales in Sydney, Australia.Emma’s research aims to find answers and solutions for people living with rare genetic conditions.

She believes every person has the right to access the best possible care and support, no matter how rare the condition they are living with.

She works with doctors to help them learn skills to think about rare diseases to fast track families moving to a diagnosis, and also to support families after a diagnosis in partnership with patient support groups.

She also does genetic research to help describe new genetic conditions and understand more about the natural history of genetic conditions: or in other words to help families understand the health and learning complications that may happen over a person’s lifetime.

She helps write management guidelines and is involved in research to find new treatments for genetic conditions.

You can learn more about Emma’s work here and also follow her on Twitter

Dr. Iva Strnadová

Professor Iva Strnadová – Professor in Special Education and Disability Studies at the UNSW Sydney

Iva’s research aims to contribute to better understanding and the improvement of the life experiences of people with disabilities, especially those most marginalized, such as people with intellectual disabilities. Combining research with advocacy is essential in her research program, which builds on supporting the self-determination (including self-advocacy) of people with intellectual disabilities, and is grounded in an innovative inclusive research approach, in which people with intellectual disabilities are included in the role of researcher.

She has a particular research interest in the well-being of people with developmental disabilities and their families over the life span, diverse transitions in the lives of people with disabilities (particularly intellectual disabilities and autism), and using arts-based methods to allow students and adults with high support needs to have a voice about matters important to them.

You can learn more about Iva’s work here, and also via this blog.

geneticist

Individuals with SATB2 need your expertise in genetic testing and your understanding of test results as parents may have been bounced around the healthcare system. So, getting a formal diagnosis may provide a clear diagnosis and some certainty for families and individuals with SATB2, especially since it is a rare disease.

psychiatrist

Individuals with SATB2 may require behavioural assessments as these individuals tend to exhibit social difficulty, hyperactivity and emotional regulation difficulties. Neuropsychological evaluations may be necessary given that learning and intellectual disabilities are common for people with SATB2.

Alison McEwen

Associate Professor Alison McEwen is a genetic counsellor and educator. She led the establishment of the Genetic Counselling Discipline within the Graduate School of Health at University of Technology Sydney (UTS).

Alison’s research interests include genetic counsellor education and training, diversity and inclusion, and the evolving roles of genetic counsellors. Alison is the second genetic counsellor to take on the role as President of the Human Genetics Society of Australasia (HGSA).

Link to Alison’s UTS profile.

UTS GC website news stories written by Alison and other stories about Genetic Counselling education.

paediatrician

Individuals with SATB2 may be assessed and referred to developmental paediatricians because they tend to exhibit developmental impairments related to sleep, hyperactivity language and learning.

paediatric ophthalmologist

Individuals with SATB2 need visual acuity assessments and visual function exams which will assist with Individualised Education Plans (IEP), and for assistance in informing materials necessary for social and daily living.

genetic counsellor

Families and individuals with SATB2 need your expertise in navigating the genetic condition, from analysis to diagnosis to living life with this rare disease, because of the barriers families may have faced with the healthcare system and the uncertainty associated with being diagnosed with a rare disease.

psychologist

Individuals with SATB2 may need behaviour support assessments which informs support plans and cognitive and behavioural therapy.
Furthermore assessments from psychologists are important in informing NDIS plans.

occupational therapist

Individuals with SATB2 require functional assessments to inform physical, cognitive, sensory, communication capacities and ADLs.
These assessments inform NDIS reports which can promote their access to assistive technology and home modifications.

physiotherapist

Individuals with SATB2 require your support to develop and improve their physical and motor skills, as well as your guidance on the use of mobility aids and equipment. These interventions may be similar to your patients with cerebral palsy and ASD.

speech therapist

Individuals with SATB2 need your expertise in swallowing, drinking and communication difficulty assessments. AAC and speech therapy are important as communication difficulties are common in people with SATB2.

dietician

Individuals with SATB2 may need your advice on improved and balanced nutrition. This is because individuals with SATB2 may have sensitivities towards certain foods, which may be similar to the needs of your clients with ASD.

Social worker

Families and individuals with SATB2 require your support with case management and service coordination, counselling and coping with adjustment to a disability, and accessing various methods of financial assistance.

craniofacial (cleft) team

Individuals with SATB2 have palatal abnormalities, including cleft palatal and high arched palate, as well as dental issues such as large teeth, so they require the team’s expertise and comprehensive management of all craniofacial abnormalities and associated conditions.

special educator

Individuals with SATB2 need your expertise in developing programs that address the individual’s learning needs in order to help with their socialisation and play skills, independence relating to self-care and emotional skills, communication development, literacy and numeracy, and thinking skills.

Their needs may be similar to your clients with ASD, ADHD and intellectual disabilities.

behavioural therapist

Individuals with SATB2 need your expertise in examining challenging behaviours that fall outside of the age-appropriate range and reduce behaviours of concern.

Support worker

Individuals with SATB2 require a range of support, including indoor personal care, education, therapy, social interactions and community access and participation.

Dr Omid Kavehei

Dr Kavehei is an academic and research leader at The University of Sydney.

His research team is focused on the development of better, smaller, more reliable and more durable sensors and systems through innovations in novel miniature devices and data analytics to enable multi-modal, and continuing long-term medical data recordings on an unprecedented scale to better answer questions in longitudinal research and to address fundamental unmet needs in the treatment of chronic conditions, at-risk population or remote (at-home) monitoring.

His work on epilepsy with a focus on seizure detection and prediction attracted the attention of major companies such as Microsoft, interested in investing in accessibility and disability.

He was with the Centre for Neural Engineering at The University of Melbourne as a microelectronic expert, contributing to the Australian biomedical engineering flagship project, the bionic eye.

He was awarded his PhD in Nano-Electronics from the University of Adelaide in 2012 with the Postgraduate University Alumni Medal, a University Doctoral Research Medal, and the 2011 South Australian Young Nanotechnology Ambassador award. In 2014, he was a Visiting Project Scientist at the University of California, Santa Barbara (UCSB).

He was awarded an Endeavor Research Fellowship by the Australian Government in 2019 and was part of the team that was awarded the 2021 Ramaciotti Awards for Biomedical Research.

He is a Senior Member of The Institute of Electrical and Electronics Engineers (IEEE).

Dalal Dawood Baumgartner

After her daughter’s diagnosis with SATB2 in 2017, Dalal and her family connected with international families at a US conference in 2018 and was motivated to support families and their loved ones living with SATB2 in Australia. She brings to the SATB2 Gene Foundation Australia sound project management experience and the drive to advocate for this rare condition through research and collaboration with international affiliated partners and universities.

Her passion for supporting children with special needs flourished whilst undergoing further study, and she realised at that point that her own daughter, Naomi, would need her undivided care.

Prior to becoming a mother, Dalal completed a Diploma in Building Studies and a Bachelor of Construction Management. Dalal has worked in the construction industry for 10 years and has gained valuable experience on a range of complex civil, infrastructure, and government projects across Sydney.

In 2018 a Master degree in Education gave her the proficiency to understand children’s developmental and support needs.

Living in Sydney with her husband Ivan and two daughters Naomi and Esther, Dalal enjoys the close proximity of Naomi’s school and therapy services.

In her spare time, she loves to dance with her kids, cook for her family, and watch on in amazement as Naomi learns to communicate through AUSLAN.